The HOX complex neighbored by the EVX gene, as well as two other homeobox‐containing genes, the GBX‐class and the EN‐class, are located on the same chromosomes 2 and 7 in humans

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Abstract
Two newly identified human homeobox‐containing genes, GBX1 and GBX2, are closely related genes, as are members of the other homeobox genes, EN‐1 and EN‐2. GBX1 and EN‐2 have been mapped to chromosome 7q36. The present study shows that GBX2 was mapped to chromosome 2q37. EN‐1 was mapped to chromosome 2q14. Moreover, two HOX complexes neighbored by the EVX gene, HOXA and HOXD, are located at chromosome 7p15‐p14 and 2q31‐q37, respectively. Thus, it is possible that these homeobox genes were linked to each other on an ancestral genome and that the ancestral chromosome segment was duplicated during evolution.