Effects of Probucol on Vascular Remodeling After Coronary Angioplasty

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Abstract
Background —We have shown that probucol reduces restenosis after balloon angioplasty. Whether probucol acted via prevention of neointimal formation or improvement in vascular remodeling could not be addressed by angiography and required the use of intravascular ultrasound (IVUS). Methods and Results —Beginning 30 days before angioplasty, 317 patients were randomly assigned to receive probucol, multivitamins, combined treatment, or placebo. Patients were then treated for 6 months after angioplasty. IVUS examination was performed immediately after angioplasty and at follow-up in 94 patients (111 segments). The cross section selected for serial analysis was the one at the angioplasty site with the smallest lumen area at follow-up. In the placebo group, lumen area decreased by −1.21±1.88 mm 2 at follow-up, and wall area and external elastic membrane (EEM) area increased by 1.50±2.50 and 0.29±2.93 mm 2 , respectively. Change in lumen area, however, correlated more strongly with the change in EEM area ( r =0.53, P =0.002) than with the change in wall area ( r =−0.13, P =0.49). Lumen loss was −1.21±1.88 mm 2 for placebo, −0.83±1.22 mm 2 for vitamins, −0.25±1.17 mm 2 for combined treatment, and −0.15±1.70 mm 2 for probucol alone ( P =0.002 for probucol, P =0.84 for vitamins). Change in wall area was similar for all groups. EEM area increased by 0.29±2.93 mm 2 for placebo, 0.09±2.33 mm 2 for vitamins only, 1.17±1.61 mm 2 for combined treatment, and 1.74±1.80 mm 2 for probucol only ( P =0.005 for probucol). Conclusions —Lumen loss after balloon angioplasty is due to inadequate vessel remodeling in response to neointimal formation. Probucol exerts its antirestenotic effects by improving vascular remodeling after angioplasty.

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