Response of Enzyme Systems to Photochemical Reaction Products

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Abstract
Exposure to photochemical reaction products inhibited the activity of glutamic dehydrogenase from Escherichia coli. With a glutamate substrate the inhibition increased at a rate comparable to the inhibition of the growth of the cells. Considerably less inhibition was observed for the reaction in the reverse direction. With increasing formaldehyde concentrations, the reaction of glutamic dehydrogenase from mammalian source was more rapidly inhibited in the reverse than in the forward direction. From the data to date, it appears that only at very low concentrations could formaldehyde produce the relationship of the reactions observed with the photochemical reaction products. There is no evidence, however, that such concentration would produce comparable magnitudes of inhibition with time.