Total syntheses of the sesquiterpenoids (±)-axamide-1, (±)-axisonitrile-1, and the corresponding C-10 epimers
- 1 December 1986
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 64 (12) , 2475-2476
- https://doi.org/10.1139/v86-408
Abstract
Total syntheses of (.+-.)-axamide-1 (1), (.+-.)-axisonitrile-1 (2), and the corresponding C-10 epimers 16 and 17 are described. The key steps of the synthetic sequence involve methylenecyclohexane annulation of 2-methyl-2-cyclopenten-1-one and TiCl4-catalyzed conjugate addition of 3-methyl-1-1,bis(trimethylsiloxy)-1-butene to the bicyclic enone 8.This publication has 1 reference indexed in Scilit:
- Quassinoids: total synthesis of dl-quassinJournal of the American Chemical Society, 1984