The Controlled Stereospecific Reduction of Cyclopentenyl Cytosine (CPE-C) to Carbodine and Isocarbodine
- 1 February 1992
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 11 (2) , 351-363
- https://doi.org/10.1080/07328319208021709
Abstract
The preferential cis-addition of hydrogen to either face of the carbocyclic double bond of enantiomerically pure cyclopentenyl cytosine (1) was achieved. The resulting saturated carbocyclic nucleosides carbodine (2) and isocarbodine (3) were evaluated against human influenza virus. Carbodine showed the greater potency against this virus but the activity of isocarbodine was still substantial.Keywords
This publication has 6 references indexed in Scilit:
- Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral propertiesJournal of Medicinal Chemistry, 1988
- Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A virusesAntimicrobial Agents and Chemotherapy, 1981
- The carbocyclic analog of cytidine, synthesis and antineoplastic activityJournal of Heterocyclic Chemistry, 1976
- The synthesis of 6'-deoxyhomonucleoside 6'-phosphonic acidsJournal of the American Chemical Society, 1968
- Hydrogenation with diimideJournal of Chemical Education, 1965
- SELECTIVITY AND MECHANISM OF DIIMIDE REDUCTIONSJournal of the American Chemical Society, 1961