DEHYDRO-ENKEPHALINS .6. DEHYDROALANINE3-ENKEPHALIN - A POTENT ENKEPHALIN ANALOG FOR THE DELTA-OPIATE RECEPTOR
- 1 January 1982
- journal article
- research article
- Vol. 20 (3) , 199-206
Abstract
The Gly3 residue in Gly2- and D-Ala2-enkephalins was replaced by .DELTA. Ala3 and Ser3 in order to examine the effect on binding to the .delta. and .mu. opiate receptors. [D-Ala2,.DELTA. Ala3, Leu5]-enkephalin maintains most of its receptor binding affinities for both sites. Apparently, the proper conjunctions of positions 2 and 3 of the enkephalin sequence are important to receptor preference and position 3 may have a very specific interaction with the .delta. receptor. The in vivo analgesic and CNS activities of the peptides are also discussed.This publication has 11 references indexed in Scilit:
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