Intravaginal Controlled Administration of Flurogestone Acetate: (III) Development of Rate-Control Vaginal Devices

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Abstract
A Rate-Control vaginal device was developed which overcomes the low bioavailability and unpredicted Q-t1/2 type release and absorption rate profiles of flurogestone acetate delivered by the currently marketed Syncro-Mate pessary. The in vitro release and vaginal absorption profiles from the Rate-Control vaginal deive were run simultaneously; a linear Q-t [quantity of drug released vs. time] relationship was obtained with a significant improvement in bioavailability. A mathematical model was developed to correlate the in vitro drug release and the vaginal absorption profiles of flurgestone acetate from the vaginal devices. The design, development and the simultaneous release and absorption profiles of flurogestone acetate from this new vaginal device were outlined and discussed.