Decreased adreno‐cortical suppression utilizing the Nebuhaler for inhalation of steroid aerosols

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Abstract
Summary: The influence on the adrenocortical function of high‐dose topical glucocorticoids inhaled via conventional devices and via a Nebuhaler®, was studied in ten children with asthma. In patients treated with dosages of beclomethasone dipropionate or budesonide, in excess of 2100 μg/1.73 m2 body surface, the 24‐h urinary excretion of free cortisol increased when the inhaler device was changed from a conventional one to a Nebuhaler. This suggests a decreased systemic influence of the inhaled glucocorticoids when these were administered via a Nebuhaler.