The Value of Serial Prostate Specific Antigen Determinations 5 Years after Radiotherapy: Steeply Increasing Values Characterize 80% of Patients

Abstract
In 1989 we reported on 124 consecutive unselected patients in whom serial polyclonal prostate specific antigen (PSA) determinations were done after radiotherapy to the prostate for clinical stages A, B, C and D1 disease. After a PSA followup of 32 months 51% of the patients had increasing values, while 41% were stable with a mean PSA level of 2.9 ng./ml. We report an additional followup of 48 months on 113 of those patients, representing a mean overall followup of 6 years.