Environmentally Induced Analgesia in Wild Mice: Comparison with Laboratory Mice

Abstract
Acute exposure to stressful stimuli causes pronounced loss of pain sensation in rodents. In this study, the analgesic effect of 3 min swimming in 20 C or 32 C water was tested in wild field (Apodemus agrarius), wild house (Mus musculus), and laboratory Swiss mice. Swim-induced analgesia was more than twofold higher in wild than in Swiss mice. Swim analgesia in both species of wild animals was equal to or higher than in mice bred for 10 generations toward high analgesia to swim stress.

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