5‐HT1ARECEPTORS IN STRESS‐INDUCED CARDIAC CHANGES: A POSSIBLE LINK BETWEEN MENTAL AND CARDIAC DISORDERS
- 20 December 2006
- journal article
- review article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 33 (12) , 1259-1264
- https://doi.org/10.1111/j.1440-1681.2006.04521.x
Abstract
SUMMARY: Mental disorders associated with chronic stressors are established risk factors for cardiac morbidity and mortality, but there is no satisfactory explanation of the mechanistic link between mental and cardiac disorders. The present article presents the hypothesis suggesting that abnormal functioning of serotonin 5‐HT1Areceptors in the lower brain stem may represent this missing link. Currently available data suggest that there may be a global downregulation of 5‐HT1Areceptors in depressive and panic patients. Recent animal results indicate that 5‐HT1Areceptors, located in the medullary raphe, possibly on the raphe–spinal presympathetic cardiomotor neurons, reduce stress‐elicited activation of these neurons. Decreased density/function of 5‐H1Areceptors in the raphe area (possibly occurring during chronic stress/depression) may lead to increased sympathetic outflow to the heart and, consequently, to the increase in noradrenalin release from the cardiac sympathetic nerve terminals.Keywords
This publication has 41 references indexed in Scilit:
- Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbitsAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2005
- Serotonin 1A Receptor Binding and Treatment Response in Late-Life DepressionNeuropsychopharmacology, 2004
- CRF1 receptor antagonist CP-154,526 reduces cardiovascular responses during acute psychological stress in rabbitsBrain Research, 2004
- 5-HT1A Receptor binding sites in post-mortem brain samples from depressed suicides and controlsJournal of Affective Disorders, 1997
- Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victimsJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1991
- Neurobehavioral contributions to cardiac arrhythmias during aversive pavlovian conditioning in the rabbit receiving digitalisJournal of the Autonomic Nervous System, 1988
- Cardiovascular Response to 8-Hydroxy-2-(di-n-Propylamino) Tetralin (8-OH-DPAT) in the Rat: Site of Action and Pharmacological AnalysisJournal of Cardiovascular Pharmacology, 1987
- Acute administration of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective 5-HT-receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat and in the spontaneously hypertensive ratJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1985
- The non-benzodiazepine anxiolytic buspirone inhibits stress-induced renin secretion and lowers heart rateLife Sciences, 1985
- Evidence that raphe-spinal neurons mediate opiate and midbrain stimulation-produced analgesiasPain, 1978