Effects of tetraacetyl-bis-dehydroascorbic acid, a derivative of ascorbic acid, on ehrlich cells and hela cells (human carcinoma cells).

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Abstract
Derivatives of ascorbic acid were synthesized, and studies were made of their effects on Ehrlich ascites carcinoma cells, in regard to inhibition and prolongation of survival time as well as morphological degeneration in HeLa cells. In a model infection study done by using tetraacetyl-bis-dehydroascorbic acid [DHA] in dd mice infected with Ehrlich cells, prolongation of survival time was nearly double in comparison to control mice. Hypertrophy due to abdominal dropsy and body weight were reduced more than in the control group. From these results, the inhibiting effect of tetraacetyl-bis-DHA was confirmed, while in the case of DHA and other derivatives, almost no inhibition and prolongation of survival time were observed. As for HeLa cells in tissue culture, tetraacetyl-bis-DHA, in a dosage of 125-250 .mu.g/ml, demonstrated morphological degeneration effects. After 125 .mu.g/ml of tetraacetyl-bis-DHA was added to a tissue culture solution of HeLa cells, the cells were washed and recultured. No growth was observed. This substance was confirmed to be an anti-HeLa substance with low toxicity.

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