ENDOMETRIAL CARCINOMA AND ORAL-CONTRACEPTIVE AGENTS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 49  (4) , 390-392
Abstract
Six patients who took oral contraceptive agents for 5-18 yr developed endometrial neoplasia. Endometrial adenocarcinoma occurred in 4 of these patients and severe adenomatous hyperplasia occurred in 2. Five of the 6 patients took sequential agents; 1 patient used a combined agent. An additional patient who took Premarin and Provera sequentially developed adenocarcinoma of the endometrium. Eighteen cases of endometrial adenocarcinoma and 7 cases of adenomatous hyperplasia in patients with long-term sequential oral contraceptive use were previously reported by others. Progestogens may not be completely protectivee against the endometrial cancer-causing potential of the estrogens, especially in the sequential regimens.

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