Linearity of Pharmacokinetics and Model Estimation of Sufentanil
Open Access
- 1 December 1995
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 83 (6) , 1194-1204
- https://doi.org/10.1097/00000542-199512000-00010
Abstract
Background: The pharmacokinetic profiles of sufentanil available in the literature are conflicting because of methodologic differences. Length of sampling and assay sensitivity are key factors involved in accurately estimating the volumes of distribution, clearances, and elimination phase. The unit disposition function of increasing doses of sufentanil were investigated and the influence of dose administered on the linearity of pharmacokinetics was assessed.Keywords
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