OBSERVATIONS ON EFFECT OF CORTICOTROPHIN IN SCHIZOPHRENIA
- 1 December 1951
- journal article
- other
- Published by American Medical Association (AMA) in A.M.A. Archives of Neurology & Psychiatry
- Vol. 66 (6) , 697-699
- https://doi.org/10.1001/archneurpsyc.1951.02320120030003
Abstract
RECENT investigations by Hoagland and Pincus1have emphasized the defective physiological responses of the schizophrenic patient to adrenocortical stimulation. Altschule and co-workers2have reported essentially normal physiological responses to corticotrophin in schizophrenic patients, with the exception of suggestive greater-than-normal changes in glucose tolerance. In an attempt to evaluate the relationship between adrenocortical activity and the psychological state, we administered corticotrophin in large doses to six patients (three men and three women) with schizophrenia. Significant data concerning these patients are presented in the accompanying table. All the patients were observed in a control period varying from two to four weeks before the administration of the corticotrophin. The influence of placebos and other drugs, such as amobarbital (amytal®),d-desoxyephedrine hydrochloride (pervitin®), amphetamine, and mescaline, was studied during the control period, or after a suitable time had elapsed after the corticotrophin was discontinued. The corticotrophin3was givenKeywords
This publication has 0 references indexed in Scilit: