The octanol/water distribution of mercury compounds
- 1 June 1985
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 57 (2) , 139-141
- https://doi.org/10.1007/bf00343125
Abstract
Lipophilicity plays an important role in the biological action of mercurials. The distribution of one inorganic and five organic mercury compounds was determined in an n-octanol/water system. Lipophilicity decreased in the order CH3HgCl, bromomercurihydroxypropane, HgCl2, chlormerodrin, p-chloromercuribenzoic acid (PCMB), p-chloromercuriphenylsulfonic acid (PCMBS). The toxicity of mercurials, as reported in the literature, appears to parallel their lipophilicity.This publication has 11 references indexed in Scilit:
- A possible physiological uptake mechanism of methylmercury by the marine bloodworm (Glycera dibranchiata)Bulletin of Environmental Contamination and Toxicology, 1980
- Use of distribution coefficients in quantitative structure-activity relationsJournal of Medicinal Chemistry, 1977
- Maternal-fetal transfer of organic and inorganic mercury via placenta and milkEnvironmental Research, 1973
- Methylmercury Poisoning in IraqScience, 1973
- Nephrotic Syndrome in Adult Africans in NairobiBMJ, 1972
- Partition coefficients and their usesChemical Reviews, 1971
- Storage of Mercury at Submolar ConcentrationsAihaj Journal, 1970
- Localization of Erythrocyte Membrane Sulfhydryl Groups Essential for Glucose TransportThe Journal of general physiology, 1965
- Interaction of Mercury with Human ErythrocytesThe Journal of general physiology, 1962
- Über den Zustand gelöster Stoffe auf Grund von VerteilungsversuchenZeitschrift für Physikalische Chemie, 1901