HYPERTONIC MANNITOL AS A TREATMENT FOR COMPLICATIONS OF CEREBRAL ARTERIOGRAPHY

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Abstract
Two patients subjected to cerebral angiography developed convulsions and hemiplegia after injection of the contrast medium. Circumstances indicated a direct toxic effect of an excessive volume of contrast material. Despite the use of accepted forms of therapy, each patient progressively deteriorated until 20 per cent mannitol solution was infused intravenously very rapidly. Thereafter, the clinical course was reversed, and complete recovery occurred. The rationale for the use of hypertonic mannitol early after such an injury is the known increase it produces in cerebral blood flow, as well as its reduction of intracranial pressure.

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