Teratogenic Effects of Sodium Arsenate in Mice

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Abstract
Single intraperitoneal injections of sodium arsenate in Swiss-Webster mice on one of days 6 to 12 of gestation resulted in increased fetal resorptions. Decreased fetal weights and a spectrum of fetal anomalies were noted in litters treated on days 6 to 11. Malformations induced were day-dependent and included exencephaly, micrognathia, protruding tongue, agnathia, open eye, exophthalmos, anophthalmia, missing pinna, cleft lip, hydrocephalus, umbilical hernia, eventration, ectrodactyly, micromelia, and shortened or twisted tail and twisted limb, or both. Skeletal defects such as fused vertebrae and fused and forked ribs were also seen.