STEREOSPECIFICITY OF BETA-ADRENOCEPTOR BLOCKADE AND RENAL VASODILATATION BY TERTATOLOL

  • 1 March 1989
    • journal article
    • research article
    • Vol. 298, 164-171
Abstract
To investigate the stereospecificity of .beta.-adrenoceptor blockade and renal vasodilatation by tertatolol, the regional hemodynamic effects of the 2 stereo-isomers of tertatolol (d-tertatolol and l-tertatolol) were compared in conscious spontaneously hypertensive rats. Furthermore, the effects of a combination of d-tertatolol and dl-propranolol were studied. l-Tertatolol and the combination of .beta.-blockers lowered heart rate and caused an early increase and a late decrease of blood pressure. l-Tertatolol, but not the combination of dl-propranolol and d-tertatolol, decreased renal resistance at 3-4 hr after injection. Injections of d-tertatolol alone did not cause any effect. Since effects of l-tertatolol are fully comparable to effects previously observed with dl-tertatolol, and d-tertatolol was devoid of any effects, both alone and in combination with dl-propranolol, we conclude that both .beta.-adrenoceptor blockade and renal vasodilatation are stereospecific for the l-isomer of tertatolol.

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