Stealth Liposomes: Five Years On

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Abstract
Incorporation of polymers, such as polyethylene glycol (PEG-lipid derivatives, or glycolipids, such as monosialoganglioside GM1; into liposomes results in sterically stabilized liposomes which have several advantages over liposome formulations traditionally used in the past, including reduced recognition and uptake by macrophages, extended circulation half-lives, dose-independent pharmacokinetics, and increased uptake in vivo by solid tumours. PEG-lipid derivatives such as PEG-distearoylphosphatidylethanolamine (PEG-DSPE) are particularily useful because of their ease of preparation and relative lack of expense. Optimum molecular weight of the PEG headgroup is approximately 2000 daltons and optimum concentration in the bilayer is 5 to 7 mol% of phospholipids. Pegylated liposomes have the additional advantage of allowing.

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