Inhibition of IgE-Mediated N-Acetylglucosaminidase and Serotonin Release from Rat Basophilic Leukemia Cells (RBL-2H3) by Tenidap: A Novel Anti-Inflammatory Agent
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 91 (4) , 369-373
- https://doi.org/10.1159/000235143
Abstract
Tenidap [(Z)-5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide] is a novel anti-inflammatory compounds of the oxindole class that currently is undergoing clinical evaluation in man. Here we demonstrate that the tenidap inhibits (IC50 = .apprx.10 .mu.M) IgE-mediated secretion of granule constituents from the rat mast cell tumor line RBL-2H3. The inhibitory effect is rapid in onset, readily reversible, and appears to be unique when compared to a representative selection of other acidic (carboxylic acids, pyrazoles and oxicams) nonsteroidal anti-inflammatory compounds.This publication has 0 references indexed in Scilit: