Two New Modes of Pd-Catalyzed Domino-Tetracyclization of Bromodienynes—5-exo-trig Cyclization Wins overβ-Hydride Elimination

Abstract
Remarkable increases of molecular complexity in a single procedural step are achieved with the title reaction. Only a slight modification in the substitution pattern on the acyclic precursor 2 can change the mode of tetracyclization to either yield skeletons of type 1 or 3 exclusively.

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