Hypercontractile cardiac states simulating hypertrophic cardiomyopathy.

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Abstract
Hypertrophic cardiomyopathy (HCM) or idiopathic hypertrophic subaortic stenosis (IHSS) was defined as an autosomal dominant myocardial disease characterized by specific physical findings, echocardiographic features, asymmetric septal hypertrophy and disordered myocardial architecture. Echocardiographic and scintiphotographic studies failed to reveal evidence of asymmetric septal hypertrophy in 4 patients with systolic anterior movement of the mitral valve and the typical auscultatory and peripheral pulse abnormalities characteristic of HCM. Postmortem examination in 1 patient demonstrated mild concentric left ventricular hypertrophy and a normal arrangement of myocardial muscle fibers. Systolic anterior movement of the mitral valve and the physical findings characteristic of HCM are not specific for the autosomal dominant myocardial disease characterized by asymmetric septal hypertrophy and abnormal septal histology.