HOST-PARASITE INTERACTIONS IN THE PATHOGENESIS OF EXPERIMENTAL RENAL CANDIDIASIS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 49  (4) , 460-467
Abstract
To study the pathogenesis of renal candidiasis, viable Candida albicans blastospores were injected directly into the left renal artery of New Zealand white rabbits. The progression of the disease was followed by light microscopy and EM over 6 day. Within 5 min after injection of the yeasts, the organisms localized within glomerular and peritubular capillaries of the cortex. Localization of yeasts within the capillaries occurred through adherence, demonstrated by the presence of surface fibrils originating from the yeast cells. Inflammatory nodules comprised of polymorphonuclear leukocytes formed within capillary lumina 2-10 h later. Many of the entrapped yeasts remained viable and extended through adjacent endothelium and epithelium by the formation of germ tubes which penetrated between or directly through intact host cells. After 24 h, numerous hyphal forms were observed within tubules of the cortex; some necrotic host cells were noted at sites of penetration. Abscesses replaced renal parenchyma in focal areas during subsequent time intervals. Thus, attachment of C. albicans to endothelium within capillaries of the cortex is a key event in the disease process. Growth of germ tubes into renal tubules provides a temporal advantage for amplification of Candida organisms.