EXPERIENCES WITH A NEW ANTIDEPRESSANT—AMITRIPTYLINE

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Abstract
Fifty cases of depression treated with amitriptyline as the sole major therapy have been described. A 75% improvement rate has been obtained in 28 cases of endogenous depression, and a 50% rate in 13 cases of reactive neurotic depression, while all three schizophrenics with depression received benefit. Side effects occurred in 40% of cases. Improvement usually occurred within two weeks and was well sustained. The outcome did not depend on previous electroconvulsive therapy or "Tofranil" therapy. The relative effectiveness of amitriptyline and imipramine is discussed.