Cross‐sectional study of the effects of immunosuppressive drugs on chronic periodontal disease in man

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Abstract
Oral examinations were performed on 102 patients receiving immunosuppressive drug therapy [mainly azathioprine and corticosteroids] following renal transplantation. A further 111 control patients matched for age and sex, were also examined. The severity of dental caries of the 2 groups was compared by considering their decayed, missing and filled teeth (DMF-T), and the severity of periodontal disease was compared in terms of pocket depths, Plaque, Calculus and Sulcular Bleeding Indices and Russell''s Periodontal Index. When comparing the 2 groups, note was made of restorations involving the gingival margins, the presence of partial dentures and recent and current antibiotic therapy. No significant differences were found between the groups with regard to age, sex distribution, plaque levels, DMF and Russell''s Periodontal Index. The immunosuppressed group had significantly less calculus, fewer restorations involving the gingival margins and significantly lower mean pocket depth. However, they did have more gingival recession than the controls and also a higher Sulcus Bleeding Index. All differences seen were maintained even when patients from both groups on antibiotics were eliminated from the analysis. Within the immunosuppresssed group no relationship was found between the length of time the drugs were taken and the periodontal variables. Patients on immunosuppressive therapy apparently show no change in susceptibility to destructive periodontal disease.