PATHOLOGY OF END-STAGE RENAL-DISEASE IN HEMODIALYSIS-PATIENTS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 15  (11) , 901-909
Abstract
The pattern of the renal disease and the pathological changes were studied in the kidneys of 80 autopsied patients who were maintained on hemodialysis for periods of up to 7 yr. Chronic pyelonephritis was most frequently encountered (25%); next in frequency were chronic glomerulonephritis (17.5%) and nephrosclerosis (17.5%). Moderate to severe intrarenal vascular changes were seen; intimal changes were most prominent. Statistically significant differences were observed in the distribution of the intimal lesions in intrarenal vessels of different calibers. Deposits of oxalate crystals, usually in the renal tubules, were encountered in all kidneys except 4. Twenty-four patients (30%) showed acquired cystic kidney disease; renal calcification was observed in 61 others. The pathogenesis of these lesions in hemodialysis kidneys and their clinical significance are discussed.

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