PRODUCTION OF ADRENAL ATROPHY BY 6-METHYL-17-ACETOXYPROGESTERONE, WITH REMARKS ON THE ADRENAL EFFECTS OF OTHER PROGESTATIONAL AGENTS
- 1 September 1959
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 65 (3) , 505-507
- https://doi.org/10.1210/endo-65-3-505
Abstract
A daily oral dose of 2 mg. of 6-methyl-17-acetoxyprogesterone to male rats and 1.5 mg. to females produced a depression of adrenal weight after two weeks. Atrophy was more marked in intact females (55% depression of weight) than in males (21%). In spayed females a subcutaneous dose of 1 mg. per rat per day for two weeks produced a 70% decrease; in the same test 1 mg. doses of progesterone and 17-(2- methallyl)-19-nortestosterone produced 20% and 14%depressions respectively, whereasneither 17a-ethynyl-17-hydroxy-5(10)-estren-3-one, nor 17-ethynyl-19-nortestosterone, nor17-acetoxy progesterone had any significant adrenal weight effect. A cold-shock test in mice after 2 weeks of daily injections of 500 Mg- of the 6 methyl derivative suggested that adrenal function was impaired.Keywords
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