Isolation and initial characterization of the mouse Dnmt3l gene
- 2 April 2001
- journal article
- animal cytogenetics-and-comparative-mapping
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 92 (1-2) , 122-126
- https://doi.org/10.1159/000056881
Abstract
We have isolated and sequenced the mouse zinc finger gene, Dnmt3l (DNA cytosine-5-methyltransferase 3-like), on mouse chromosome 10, showing similarity to members of the DNMT3/Dnmt3 family. The Dnmt3l protein contains an ADD zinc finger, which Dnmt3l shares with other Dnmt3 family members and Atrx. RT-PCR analysis showed Dnmt3l expression in testis, thymus, ovary, and heart, as well as in 7-day, 15-day, and 17-day mouse embryos.Keywords
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- Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityPublished by Elsevier ,1992