Mechanical and Metabolic Effects of β‐Receptor Stimulators, the C‐Terminal Octapeptide of Cholecystokinin, and Prostaglandin E2on the Isolated, Depolarized Sphincter of Odd

Publisher Website
Google Scholar
Abstract
Similar to their actions on normally polarized, isolated sphincter of Oddi, the β‐receptor stimulators isoprenaline and terbutaline, and prostaglandin E2produced relaxation of the depolarized preparation. The relaxation was accompanied by an increase in the intracellular content of cyclic AMP. In contrast to its relaxing effect on normally polarized sphincter preparations, the C‐terminal octapeptide of cholecystokinin (C8‐CCK) contracted or had no effect on the depolarized sphincter. There was no change or a small decrease in the content of cyclic AMP in the muscle. It is suggested that the relaxing effects of β‐receptor stimulators and prostaglandin E2on isolated sphincter of Oddi, and the simultaneous increase in cyclic AMP‐content are mediated by processes independent of the electrical activity of the membrane. However, C8‐CCK mediated relaxation and increase in cyclic AMP is dependent on the membrane potential.

This publication has 19 references indexed in Scilit: