ANALYSIS OF A HERTWIG EFFECT INDUCED BY THE IRRADIATION OF RANA PIPIENS SPERM WITH ULTRAVIOLET

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Abstract
Some of the underlying parameters of the classical Hertwig effect were studied. The irradiation of R. pipiens sperm with an incremental regime of UV was accompanied by an initial decrease in viability followed by its recrudescence at higher doses. The most impaired survival was concomittant with aneuploid chromosomal conditions. The types of growth abnormalities were also somewhat dose-specific particularly at 8 s, where acephalic embryos characterized the various aneuploid states observed. The relationship between aneuploidy, growth anomalies and the important question of the mechanism of chromosomal loss (or removal) were discussed. That more fundamental, perhaps molecular, events may underlie the Hertwig effect was further demonstrated by the severe depression in mitotic activity that accompanied the aneuploid conditions.