Two New Thalassaemic Syndromes: a) Homozygous Alpha-Thalassaemia. b) Cooley-Like Disease due to Homozygous Elevated Hb A2 Without Microcythaemia

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Abstract
Two new syndromes are described due to interaction of thalassemic genes: a disease due to homozygous alpha-thalassemia and a disease due to homozygous elevated Hb A2 without microcythemia. The former disease differs from that described by Lie-Injo-Luan Eng because it occurs in early childhood and is not lethal notwithstanding a chronic severe anemia. The latter is similar to Cooley''s disease differing from this, however, in the very delayed course, the absence of micro-cytosis and increased osmotic resistance, the normal level of Hb F, the absence in the bone marrow of microerythroblastosis with negativity of Hotchkiss''s test.