Development of Lactic Dehydrogenase Isozymes in the Chick Embryo.

Abstract
Summary It was observed that 6 LDH isozymes were present in chick embryonic organs. Five of these isozymes occurred in developing liver while the 6th type was one of 3 isozymes found in brain and spleen. Brain and spleen exhibited only slight changes in isozyme content during maturation while more extensive changes occurred in liver. The demonstration of LDH isozymes of liver transplanted to the chorioallantoic membrane revealed that there was a reduction in the number of isozymes suggestive of a return to a less differentiated state.

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