Cloning and nucleotide sequence of the mphB gene for macrolide 2′-phosphotransferase II in Escherichia coli
- 1 November 1996
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 144 (2-3) , 197-202
- https://doi.org/10.1016/0378-1097(96)00362-x
Abstract
Macrolide 2'-phosphotransferase II [MPH(2')II] inactivates macrolide antibiotics. The mphB gene for MPH(2')II was cloned from Escherichia coli and sequenced. Analysis of the nucleotide sequence indicated that mphB encoded a protein of 302 amino acids with a molecular mass of 34483 Da. The carboxy terminal region of the deduced protein contained a sequence that resembled a conserved functional domain in aminoglycoside phosphotransferases.Keywords
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