Antigen decoding by T lymphocytes: from synapses to fate determination
- 1 June 2001
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 2 (6) , 487-492
- https://doi.org/10.1038/88678
Abstract
Naïve T lymphocytes sense foreign antigens by establishing contacts with dendritic cells (DCs). At the immunological synapse between the T cell and a DC, T cell receptors (TCRs) are serially engaged and triggered by specific ligands. The amount and duration of TCR triggering and the efficiency of signal amplification determine T cell commitment to proliferation and differentiation. The nature and availability of DCs bearing antigen and costimulatory molecules shape the T cell response, giving rise to distinct functional outputs such as effector and memory T cell generation or T cell tolerance.Keywords
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