Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Top Cited Papers
- 6 March 2015
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 347 (6226) , 1138-1142
- https://doi.org/10.1126/science.aaa1934
Abstract
Cellular diversity in the brain revealed: The mammalian brain has an extraordinarily large number of cells. Although there are quite a few different cell types, many cells in any one category tend to look alike. Zeisel et al. analyzed the transcriptomes of mouse brain cells to reveal more than meets the eye. Interneurons of similar type were found in dissimilar regions of the brain. Oligodendrocytes that seemed to be all of one class were differentiated by their molecular signatures into a half-dozen classes. Microglia associated with blood vessels were distinguished from look-alike perivascular macrophages. Thus, the complex microanatomy of the brain can be revealed by the RNAs expressed in its cells. Science , this issue p. 1138Keywords
Funding Information
- European Research Council (261063)
- Human Frontier Science Program
- Karolinska Institutet
- Swedish Cancer Society (CAN2013/852)
- Swedish Research Council
- European Union (FP7/Marie Curie Integration Grant EPIOPC)
- Åke Wiberg Foundation
- Karolinska Institutet Research Foundations
- Svenska Läkaresällskapet
- Clas Groschinskys Minnesfond
- Hjärnfonden
This publication has 35 references indexed in Scilit:
- Hippocampal CA1 pyramidal cells form functionally distinct sublayersNature Neuroscience, 2011
- Mechanisms of Inhibition within the Telencephalon: “Where the Wild Things Are”Annual Review of Neuroscience, 2011
- The Largest Group of Superficial Neocortical GABAergic Interneurons Expresses Ionotropic Serotonin ReceptorsJournal of Neuroscience, 2010
- Computer Control of Microscopes Using µManagerCurrent Protocols in Molecular Biology, 2010
- Common Origins of Hippocampal Ivy and Nitric Oxide Synthase Expressing Neurogliaform CellsJournal of Neuroscience, 2010
- Genomic–anatomic evidence for distinct functional domains in hippocampal field CA1Proceedings of the National Academy of Sciences, 2009
- Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasisNature, 2008
- Imaging individual mRNA molecules using multiple singly labeled probesNature Methods, 2008
- Genome-wide atlas of gene expression in the adult mouse brainNature, 2006
- Coupled two-way clustering analysis of gene microarray dataProceedings of the National Academy of Sciences, 2000