Drug Release from Semi-Solid Matrix Systems in Hard Capsules
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 15 (14-16) , 2407-2417
- https://doi.org/10.3109/03639048909052538
Abstract
The authors have prepared hard capsules containing semisolid matrix systems with fatty excipients and acetylsalicylic acid (ASA) in order to decrease the dissolution rate of this active substance. With excipients like Gélucires and Simulsols, they obtained matrix systems easy to prepare and having a good stability, at least until 37°C. These systems release in vitro acetylsalicylic acid in about 8 hours; but administered p.o. to man they release ASA too rapidly in less then 4 hoursKeywords
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