THE MENOPAUSAL SYNDROME

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Abstract
The principle of estrogen replacement therapy in the management of the menopausal syndrome is well established as sound. Estrogen preparations of proved potency have become available during the past decade, and many satisfactory therapeutic results have been reported. The standard method of administration of these estrogen preparations, however, is far from satisfactory as it requires frequent hypodermic or intramuscular injections of the hormone preparations, usually in oil solutions, repeated as often as two to three times each week. Obviously, if it was possible to supply a patient's estrogen requirement for weeks or even months with a single injection, the ideal method of replacement therapy would be more nearly attained. An approach toward such an ideal method came to hand in 1937 when Deanesly and Parkes1 announced a new technic in hormone administration whereby solid pellets of crystalline hormone were implanted subcutaneously to be absorbed slowly over a long period

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