Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms*
- 14 July 1997
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 62 (1) , 60-73
- https://doi.org/10.1016/s0009-9236(97)90152-1
Abstract
Thiopurine methyltransferase (TPMT) catalyzes the S‐methylation of thiopurine drugs. TPMT activity is regulated by a common genetic polymorphism that is associated with large individual variations in...Keywords
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