Mutation of the Androgen-Receptor Gene in Metastatic Androgen-Independent Prostate Cancer
- 25 May 1995
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 332 (21) , 1393-1398
- https://doi.org/10.1056/nejm199505253322101
Abstract
Metastatic prostate cancer is a leading cause of cancer-related death in men. The rate of response to androgen ablation is high, but most patients relapse as a result of the outgrowth of androgen-independent tumor cells. The androgen receptor, which binds testosterone and stimulates the transcription of androgen-responsive genes, regulates the growth of prostate cells. We analyzed the androgen-receptor genes from samples of metastatic androgen-independent prostate cancers to determine whether mutations in the gene have a role in androgen independence.Keywords
This publication has 27 references indexed in Scilit:
- The human androgen receptor: Domain structure, genomic organization and regulation of expressionPublished by Elsevier ,2003
- Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesteroneMolecular Endocrinology, 1993
- Threonine on Amino Acid Position 868 in the Human Androgen Receptor Is Essential for Androgen Binding Specificity and Functional ActivityBiochemical and Biophysical Research Communications, 1993
- DNA sequence of the androgen receptor in prostatic tumor cell lines and tissue specimens assessed by means of the polymerase chain reactionThe Prostate, 1993
- Challenges in the Management of Prostate CancerPublished by Wiley ,1992
- Single base mutations in the human androgen receptor gene causing complete androgen insensitivity: rapid detection by a modified denaturing gradient gel electrophoresis techniqueMolecular Endocrinology, 1992
- Cancer statistics, 1992CA: A Cancer Journal for Clinicians, 1992
- Androgen receptors in endocrine‐therapy‐resistant human prostate cancerInternational Journal of Cancer, 1991
- A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgensBiochemical and Biophysical Research Communications, 1990
- Gene regulation by steroid hormonesCell, 1989