PHARMACOLOGICAL CHARACTERIZATION OF THE RABBIT LUNG STRIP

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 23  (2) , 223-232
Abstract
Isolated rabbit lung parenchymal strips contracted to epinephrine (E), norepinephrine (NE), phenylephrine (PE), histamine, carbachol, PG[prostaglandin]F2.alpha., bradykinin and 5-HT [serotinin]. Lung strips which were maximally contracted to histamine, carbachol and PGF2.alpha., relaxed to isoproterenol, salbutamol, terbutaline and PGE1. They exhibited superimposed contractions to E, NE and PE. Atropine and mepyramine selectively antagonized contractions to carbachol and histamine, respectively, without modifying contractions to the sympathomimetic agents. Phentolamine antagonized responses to E, NE and PE. The .alpha.- and .beta.-adrenergic and H1-histamine receptors may be present in the rabbit lung strip.

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