Changes in glial cells of the octopus brain after 6-hydroxydopamine administration

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Abstract
Incubation of brain slices from the cephalopod Octopus vulgaris with [3H]noradrenaline, followed by radioautography, showed preferential accumulation of the isotope in glial cells. Evidence that the glial cells take up catecholamines in vivo was obtained with 6-hydroxydopamine (6-OHDA). Five or more days after injection of 6-OHDA into the blood, glial cells in the median frontal and superior buccal lobes contained masses of osmiophilic inclusions characteristic of degenerating cells, or lost many of their processes. No changes in the structure of neurons in these brain lobes were observed at any period up to 15 days after injection. In the optic lobes nerve terminals and glial cells showed degenerative alterations.