Determination of lovastatin acid in serum by gas chromatography/mass spectrometry
- 1 May 1989
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 3 (5) , 132-134
- https://doi.org/10.1002/rcm.1290030504
Abstract
The acid form of lovastatin, an HMG-CoA reductase inhibitor, was analyzed by gas chromatography/negativeion chemical ionization mass spectrometry after derivatization with pentafluorobenzyl bromide and bis-(trimethylsilyl)trifluoroacetamide (BSTFA). Mass spectrometry of this derivative produced a dominant [M–181]− ion under chemical ionization conditions using ammonia as the reagent gas. The limit of detection was approximately 2 pg injected on column.Keywords
This publication has 3 references indexed in Scilit:
- Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.Proceedings of the National Academy of Sciences, 1983
- Combined capillary column gas chromatography negative ion chemical ionization mass spectrometry of prostanoidsJournal of Mass Spectrometry, 1983
- Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers.Journal of Clinical Investigation, 1982