The Influence of Transfusions from Unrelated Donors upon Marrow Grafts Between Histocompatible Canine Siblings

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Abstract
Previous studies indicated that marrow grafts between canine siblings matched by serologic histocompatibility typing and for non-reactivity in mixed leukocyte culture uniformly resulted in prompt and sustained engraftment. In contrast, marrow rejection was the rule when the recipient was given a single prior blood transfusion from the matched sibling marrow donor. The present study investigated the effect of multiple prior blood transfusions from randomly selected unrelated dogs on the outcome of marrow grafts between histocompatible siblings. Recipients were given three transfusions on each of three occasions, 24, 17 and 10 days before grafting. Recipients were prepared for grafting by exposure to 1500 R whole body irradiation followed within 4 hr by infusion of marrow from the matched sibling. Seven of the 11 recipients had prompt and sustained marrow engraftment and survived beyond 70 days. Four recipients died between 9 and 40 days, three of marrow rejection and one with a functioning graft and graft-vs-host disease. The data indicated that multiple prior transfusions from unrelated dogs can in some cases immunize a recipient and prevent subsequent successful marrow engraftment from a histocompatible canine sibling.

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