Experimental reorganization of the cerebellar cortex. VII. Effects of late X‐irradiation schedules that interfere with cell acquisition after stellate cells are formed
- 1 January 1976
- journal article
- Published by Wiley in Journal of Comparative Neurology
- Vol. 165 (1) , 65-75
- https://doi.org/10.1002/cne.901650106
Abstract
In Long-Evans rats the area of the cerebellum was irradiated with multiple doses of low-level X-ray beginning on day 12 after the bulk of stellate cells were acquired. The treatment spared basket, stellate and early-forming granule cells but led to a substantial reduction in the total granule cell population and a correlated miniaturization of the cerebellar cortex. Nevertheless most Purkinje cells had normally shaped planar dendritic arbors, with an upward directed stem dendrite, several smooth branches and a multitude of spiny branchlets. The frequency piling up of spiny branchlets near the surface was attributed to the truncation of the bed of parallel fibers by this radiation schedule. In this last paper of the series the accumulated results are summarized and evaluated. The hypothesis is offered that while the growth of the Purkinje cell perikaryon is an autonomous process, the oriented perpendicular growth of a single stem dendrite depends on the presence of basket cell axons, the outgrowth of smooth branches on the presence of stellate cell axons, and the proliferation of spiny branchlets on interaction with parallel fibers. The parallel fibers are responsible for the orthogonal, planar growth of the dendritic arbor and a hypothesis is offered about the mechanisms involved.Keywords
This publication has 21 references indexed in Scilit:
- Experimental reorganization of the cerebellar cortex. V. Effects of X-irradiation schedules that allow or prevent cell acquisition after basket cells are formedJournal of Comparative Neurology, 1976
- Experimental reorganization of the cerebellar cortex. V. Effects of early X-irradiation schedules that allow or prevent the acquisition of basket cellsJournal of Comparative Neurology, 1976
- Postnatal development of the cerebellar cortex in the rat. IV. Spatial organization of bipolar cells, parallel fibers and glial palisadesJournal of Comparative Neurology, 1975
- Experimental reorganization of the cerebellar cortex. IV. Parallel fiber reorientation following regeneration of the external germinal layerJournal of Comparative Neurology, 1973
- Experimental reorganization of the cerebellar cortex. III. Regeneration of the external germinal layer and granule cell ectopiaJournal of Comparative Neurology, 1973
- Postnatal development of the cerebellar cortex in the rat. III. Maturation of the components of the granular layerJournal of Comparative Neurology, 1972
- Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layerJournal of Comparative Neurology, 1972
- Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layerJournal of Comparative Neurology, 1972
- Autoradiographic and histological studies of postnatal neurogenesis. III. Dating the time of production and onset of differentiation of cerebellar microneurons in ratsJournal of Comparative Neurology, 1969
- The Cerebellum as a Neuronal MachinePublished by Springer Nature ,1967