Marrow-dependent cells depleted by 89Sr mediate genetic resistance to herpes simplex virus type 1 infection in mice

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Abstract
Adult mice resistant to infection with 106 plaque-forming units of a virulent strain of herpes simplex virus type 1 [HSV-1] were treated with 89Sr to abrogate marrow-dependent cell functions. Treated mice were much more susceptible to the HSV-1 infection than untreated mice. The virus persisted in the visceral tissues of 89Sr-treated mice for 3 or more days post-infection but not in those of untreated mice. The virus spread to the spinal cords of treated but not untreated mice. A marrow-dependent cell appeared to mediate resistance to HSV-1 by controlling the infection early after inoculation and not allowing the infection to spread to the CNS.