Ticrynafen: A New Thiazide-Like but Uricosuric Antihypertensive Diuretic

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Abstract
EVER since the late 1950's, when the oral thiazide congeners were introduced clinically, diuretic therapy has been the mainstay in the treatment of hypertension. Indeed, this class of diuretic agents has been singled out by the Joint National Committee on the Detection, Evaluation, and Treatment of High Blood Pressure as the first step in antihypertensive therapy.1 Notwithstanding the importance of this major class of diuretics, the search for improved diuretics and other antihypertensive agents has continued. Diuretic compounds have been synthesized and introduced clinically that can be more effective in patients with chronic renal disease and impaired renal excretory function, . . .