Patterns of Spontaneous Hemostasis in the Blood Vessels of the Rabbit's Ear

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Abstract
1. A technique has been developed for the continuous recording of the amount of blood flowing from single vessels following their transection. 2. the blood is washed away by a stream of saline flowing at constant rate. the mixture of blood and saline crosses a beam of blue light directed to a phototube. the output of the associated circuit is fed into an ink writer which records the changes in the concentration of erythrocytes suspended in the saline. 3. Experiments performed with this technique on the small vessels of the rabbit's ear have revealed two basic patterns of hemostasis. 4. the “arterial pattern” is characterized by a sudden outburst of blood when the vessel is cut, followed within a few seconds by a marked decrease in the rate of blood outflow. Therefore, the record begins with a sharp initial peak. Rhythmic fluctuations in the rate of blood outflow which might be due to vasomotion, are often seen in this type of patterns. 5. the “venous pattern” lacks the initial peak, looking roughly trapezoidal with a hump or plateau. 6. A mixed “peak and hump” pattern is also often found; its significance is discussed. 7. in a small group of experiments, the influence of mechanical pressure, infiltration of the perivascular tissue with local anesthetics, and the injection of heparine and antiplatelet serum on the patterns of hemostasis were studied.