Effects of 48/80 on the mechanical properties of the lungs.

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Abstract
Injection of 48/80 [a condensation product of p-methoxphenethylmethylamine and formaldehyde] into the right ventricle of paralyzed, vagotomized, artifically ventilated cats increased total pulmonary resistance (RL), end-expiratory transpulmonary pressure, and pulmonary arterial pressure, and decreased pulmonary compliance (CL), functional residual capacity, and femoral arterial pressure. CL decreasedbefore RL increased; the changes were prolonged and incompletely reversed by large inflations of the lungs. The changes in CL and RL were similar to those produced by right ventricular injections of histamine, and suggest that 48/80 leads to constriction of alveolar ducts. Premedication with polymethylene salicylic acid prevented these effects, but mepyramine maleate, tripelennamine hydrochloride, lysergic acid butanolamide, and heparin were not effective. These findings are consistent with the possibility that the 48/80-induced changes depend on histamine release.