A Mg++-ATP Dependent Storage Mechanism in the Amine Granules of the Adrenal Medulla
- 1 January 1962
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 6 (1) , 47-53
- https://doi.org/10.1159/000135133
Abstract
The amine granules of the adrenal medulla take up and concentrate adrenalin and dopamine in vitro at low external concentrations of the added amines. The storage mechanism is activated by ATP and Mg++ and is blocked by some tranquillizers[long dash]especially reserpine[long dash]at low concentrations. It is also inhibited by 4 adrenergic blocking agents, dibenamine, phenoxybenzamine, dihydroergotamine and 3,4-dichloroisopropylnoradrenalin.Keywords
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